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Inflammatory Bowel Diseases (IBD), Irritable Bowel Syndrome (IBS) and eating disorders are common pathologies, sharing the same pathophysiological aspect: intestinal dysfunction. According to many proteomic studies, a lot of intestinal proteins would be involved in those pathologies and some nutrients like amino acids, carbohydrates and omega-3 fatty acids, could modulate intestinal protein metabolism in Humans. The GutProt database aims to store proteomic data, involved in intestinal dysfunction. In 2010, the laboratory Inserm UMR 1073 "Nutrition, inflammation and dysfunction of gut-brain axis" decided to developpe a new database in order to store proteomic data involved in intestinal dysfunction and facilitate biomarkers and therapeutic targets research. The GutProt database will be available at the end of the year 2012.
Activities
The research activities of our group, integrated in the IRIB Institute, are mainly dedicated to the study of eating disorders, irritable bowel syndrome (IBS) and inflammatory bowel diseases (IBD). These pathologies share common features of intestinal inflammation and dysregulation of the gut-brain axis and offer great opportunities for innovative therapeutic strategies (immunonutrition, neurostimulation). Our projects explore the underlying mechanisms of these diseases from the molecular level to clinical trials. This broad range of research from the bench to the bedside is the result of our research strategy that brings together basic and clinical sciences, in a tight collaboration between laboratory scientists and health professionals. Our team has an active research strategy which also drives the translation of research from the laboratory to patenting and creation of biotech companies entrepreneurship (Brainworks Applied®).
Team
- 30 Teacher-researchers, researchers, engineers, technicians
- 12 Graduate students, 3 undergraduate students
Research topics
- Nutrients and intestinal metabolism during inflammation
- Physiology and dysfunction of gut-brain axis
- Pathophysiology of eating-disorders and obesity
- Pathophysiology of Irritable Bowel Syndrome and Inflammatory Bowel Diseases
- Innovative therapeutics (immunonutrition, neurostimulation) and biotech industries
Technical facilities
- Intestinal models: cell lines, human intestinal explants, experimental colitis
- Mass spectrometric analysis and in vivo isotopic studies, proteomics
- Body composition in rodents and humans (DEXA)
- Investigation platform for digestive function (motility, sensitivity, endoscopy)
- Neurostimulation and neuronavigation systems
